一名急性起病的1型糖尿病合并严重肾功能不全患者的全身性癫痫持续状态：病例报告及文献复习
Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review.
作者信息
Ohara Nobumasa, Koda Ryo, Watanabe Hirofumi, Iino Noriaki, Ohashi Kazumasa, Terajima Kenshi, Ozawa Tetsutaro, Ikeda Yohei, Sekiguchi Hiroshi, Ohashi Hitomi, Yamaguchi Seigo
机构信息
Department of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
出版信息
Intern Med. 2017;56(15):1993-1999. doi: 10.2169/internalmedicine.56.8304. Epub 2017 Aug 1.
A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. In this T1D case with CKD, severe hyperglycemia in conjunction with other metabolic insults, such as uremia, hyponatremia, and hypocalcemia, probably provoked his seizure despite the severe ketonemia.
一名65岁的日本男性，患有晚期慢性肾脏病（CKD），突发1型糖尿病（T1D），伴有严重急性肾损伤，表现为全身强直阵挛性癫痫持续状态。纠正糖尿病酮症酸中毒后，他的癫痫发作缓解且未复发。虽然高血糖是急性症状性癫痫发作（ASS）的重要原因，但酮症性高血糖患者发生ASS的频率较低。在这个患有CKD的T1D病例中，尽管存在严重酮血症，但严重高血糖与其他代谢紊乱，如尿毒症、低钠血症和低钙血症一起，可能诱发了他的癫痫发作。
Zotero 插件