Rajc Jasmina, Gugić Damir, Fröhlich Irena, Marjanović Ksenija, Dumenčić Boris
Clinical Department of Pathology and Forensic Medicine, Osijek University Hospital, J. Huttlera 4, 31000 Osijek, Croatia; Faculty of Medicine Osijek, University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia.
Faculty of Medicine Osijek, University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia; Clinical Department of Oncology, Osijek University Hospital, J. Huttlera 4, 31000 Osijek, Croatia.
Pathol Res Pract. 2017 Sep;213(9):1102-1108. doi: 10.1016/j.prp.2017.07.019. Epub 2017 Jul 24.
Nectins are Ca2-independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions and regulate several cellular activities including the entry of some viruses. Nectin-4 has recently been shown as a metastasis-associated protein in several cancers. In the following study, we have evaluated the expression of Nectin-4 inthe luminal B HER2 negative subtype breast cancer. The study group consisted of 147 patients presenting with primary unilateral breast carcinoma with no evidence of distant metastases. Nectin-4 protein expression was assessed by immunohistochemistry and the results were correlated with the clinical data using Kaplan-Meier curves, univariate and multivariate stepwise proportional-hazard analysis (Cox model). Nectin-4 overexpression was significantly correlated with the tumour size (p<0.05; Fisher's Exact Test), also Nectin-4 expression was negatively associated with overall survival, disease free survival and distant relapse free survival with the same significance (p<0,001; Kaplan-Meier, Cox model). We did not find statistically significant correlation between Nectin-4 and age, ER, PR, age, lymph node metastasis, tumour differentiation, histologicalsubtype and Ki-67proliferation index. We suggest that Nectin-4 is a relevant prognostic factor and a therapeutic target in luminalB (HER2 negative) breast cancer.
NECTIN蛋白是一类不依赖钙离子的免疫球蛋白（Ig）超家族蛋白，参与上皮和内皮连接的组织构建，并调节包括某些病毒进入在内的多种细胞活动。NECTIN-4最近被证明是几种癌症中的一种转移相关蛋白。在以下研究中，我们评估了NECTIN-4在腔面B型HER2阴性亚型乳腺癌中的表达。研究组由147例原发性单侧乳腺癌患者组成，无远处转移证据。通过免疫组织化学评估NECTIN-4蛋白表达，并使用Kaplan-Meier曲线、单因素和多因素逐步比例风险分析（Cox模型）将结果与临床数据相关联。NECTIN-4过表达与肿瘤大小显著相关（p<0.05；Fisher精确检验），同样，NECTIN-4表达与总生存期、无病生存期和远处无复发生存期呈负相关，具有相同的显著性（p<0.001；Kaplan-Meier，Cox模型）。我们未发现NECTIN-4与年龄、雌激素受体（ER）、孕激素受体（PR）、年龄、淋巴结转移、肿瘤分化、组织学亚型和Ki-67增殖指数之间存在统计学显著相关性。我们认为NECTIN-4是腔面B型（HER2阴性）乳腺癌的一个相关预后因素和治疗靶点。
