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皮肤搔抓障碍中症状严重程度的临床相关因素。

Clinical correlates of symptom severity in skin picking disorder.

作者信息

Grant Jon E, Chamberlain Samuel R

机构信息

Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

Department of Psychiatry, University of Cambridge, Cambridge and Peterborough NHS Foundation Trust (CPFT), UK.

出版信息

Compr Psychiatry. 2017 Oct;78:25-30. doi: 10.1016/j.comppsych.2017.07.001. Epub 2017 Jul 8.

Abstract

BACKGROUND

Skin picking disorder (SPD) remains poorly understood with limited data regarding its underlying pathophysiology and appropriate treatment choices. One approach to refining our treatment of SPD might be to better understand the range of illness severity and the clinical associations with severity.

METHODS

125 adults aged 18 to 65 with a primary, current DSM-5 diagnosis of SPD were assessed for the severity of their picking, using the Skin Picking Symptom Assessment Scale, and related mental health symptoms. To identify clinical and demographic measures associated with variation in disease severity, we utilized the statistical technique of partial least squares (PLS).

RESULTS

Greater SPD symptom severity was associated with higher Barratt attentional impulsiveness and motor impulsivity, higher Eysenck impulsivity, higher state anxiety/depression, having a current anxiety disorder, and having a lifetime substance use disorder.

CONCLUSIONS

The present analysis is, to our knowledge, the most complete assessment of clinical variables and their relationship to illness severity in a sample of adults with SPD. Aspects of impulsivity and anxiety are both strongly associated with worse illness severity, and functional disability, in SPD. Treatment approaches should incorporate these as possible treatment targets when developing new treatment approaches to this disorder.

摘要

背景

人们对皮肤搔抓障碍(SPD)的了解仍然有限,关于其潜在病理生理学和适当治疗选择的数据较少。优化我们对SPD治疗的一种方法可能是更好地了解疾病严重程度的范围以及与严重程度相关的临床关联。

方法

使用皮肤搔抓症状评估量表对125名年龄在18至65岁之间、目前主要诊断为DSM-5标准下SPD的成年人的搔抓严重程度及相关心理健康症状进行评估。为了确定与疾病严重程度变化相关的临床和人口统计学指标,我们采用了偏最小二乘法(PLS)统计技术。

结果

较高的SPD症状严重程度与较高的巴拉特注意冲动性和运动冲动性、较高的艾森克冲动性、较高的状态焦虑/抑郁、目前患有焦虑症以及有终生物质使用障碍有关。

结论

据我们所知,本分析是对患有SPD的成年人样本中临床变量及其与疾病严重程度关系的最全面评估。冲动性和焦虑方面均与SPD中更严重的疾病严重程度和功能残疾密切相关。在开发针对这种疾病的新治疗方法时,治疗方法应将这些作为可能的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cecd/5609656/d4ce47574bab/gr1.jpg

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