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2017年巴基斯坦丙型肝炎的诊断、管理与预防

Diagnosis, Management And Prevention Of Hepatitis C In Pakistan 2017.

作者信息

Umar Muhammad, Khaar Hamama-Tul-Bushra, Akhter Tayyab Saeed, Aslam Faiza, Ahmad Syed Irfan, Asghar Rai Mohammad, Khurram Mohammad, Hussain Tassawar, Salamat Amjad, Khan Anwar A, Minhas Zahid Mahmood, Shah Hasnain Ali, Farooqui Javed, Naqvi Asif Abbas, Mohsin Aftab, Bhutta Sohail Iqbal, Hasnain Syed Sibt Ul, Qureshi Saleem, Adam Tashfeen, Uddin Moazzam, Tayyab Ghias-U-Nabi, Shoaib Atifa, Ambreen Saima, Shahzad Arslan, Ikram Nadeem, Nisar Gul, Khan Mohammad Mujeeb, Osama Mohammad

机构信息

Centre for Liver and Digestive Diseases (CLD), Rawalpindi Medical College, Holy Family Hospital, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2016 Oct-Dec;28(4 Suppl 1):S839-S882.

Abstract

AIMS AND OBJECTIVES

Since the advent of direct acting antiviral agents, there is a revolutionary change in the management of HCV infection. Newer drugs with different mechanism of action are being introduced and are expected to be available in coming few months in Pakistan as well. The main purpose of the guideline is to review and induct the latest research in field of HCV infection in Pakistani perspective so that our healthcare professionals can apply the new recommendations in timely and judicial manner. Target groups of guidelines are general physicians treating hepatitis C, hepatologists and gastroenterologists. Other beneficiaries of these guidelines are public health institutions of Pakistan, which provide free treatment to deserving patients under National Hepatitis Prevention and Control Program and Pakistan Bait-ul- Mal Program.

METHODOLOGY

These guidelines are based on the review of National consensus practice guidelines: Diagnosis, Management and Prevention of Hepatitis C Pakistan 2009. Published data in National and International Journals searched with the help of Google search and pub med, and 2015-16 guidelines of HCV by AASLD, EASL, APASL and WHO. Local studies are preferably added with references to enhance the Pakistani perspective. Evidence was also taken from published studies. Recommendations have been based upon evidence from national publications on the subject and scientific presentations at national liver meeting as well from experts' personal experience and opinion.

摘要

目的与目标

自直接作用抗病毒药物问世以来,丙型肝炎病毒(HCV)感染的治疗发生了革命性变化。具有不同作用机制的新型药物不断推出,预计在未来几个月也将在巴基斯坦上市。本指南的主要目的是以巴基斯坦的视角回顾和引入HCV感染领域的最新研究成果,以便我们的医疗保健专业人员能够及时、合理地应用这些新建议。本指南的目标群体是治疗丙型肝炎的普通内科医生、肝病学家和胃肠病学家。这些指南的其他受益者是巴基斯坦的公共卫生机构,它们在国家肝炎预防和控制计划以及巴基斯坦慈善机构计划下为符合条件的患者提供免费治疗。

方法

本指南基于对《2009年巴基斯坦丙型肝炎诊断、管理和预防国家共识实践指南》的回顾。借助谷歌搜索和PubMed搜索国家和国际期刊上发表的数据,以及美国肝病研究学会(AASLD)、欧洲肝脏研究学会(EASL)、亚太肝脏研究学会(APASL)和世界卫生组织(WHO)2015 - 16年的HCV指南。优先纳入本地研究并附上参考文献,以强化巴基斯坦视角。证据也取自已发表的研究。建议基于该主题的国家出版物中的证据、全国肝脏会议上的科学报告以及专家的个人经验和意见。

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