Lai Jianbo, Lu Qiaoqiao, Huang Tingting, Hu Shaohua, Xu Yi
Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine.
Key Laboratory of Mental Disorder Management in Zhejiang Province.
Neuropsychiatr Dis Treat. 2017 Jul 19;13:1905-1908. doi: 10.2147/NDT.S137923. eCollection 2017.
Quetiapine, an atypical antipsychotic, has been extensively used in patients with bipolar disorder. Overdose of quetiapine can result in severe complications, such as coma, seizure, respiratory depression, arrhythmia, and even death. However, the paucity of toxicological evaluation in adolescence causes more potential risks in this population. Herein, we present a case of hypotension and convulsive syncope after exposure to a small dose of quetiapine in a 16-year-old who was diagnosed with bipolar disorder. After cessation of quetiapine, no additional convulsive movements were reported. This case indicates that even in young patients without predisposing factors, close monitoring of adverse effects should be warranted for safety concerns, especially at the initiation of quetiapine treatment.
喹硫平是一种非典型抗精神病药物，已广泛应用于双相情感障碍患者。过量服用喹硫平可导致严重并发症，如昏迷、癫痫发作、呼吸抑制、心律失常，甚至死亡。然而，青少年毒理学评估的缺乏给这一人群带来了更多潜在风险。在此，我们报告一例16岁双相情感障碍患者在服用小剂量喹硫平后出现低血压和惊厥性晕厥的病例。停用喹硫平后，未再报告有惊厥性发作。该病例表明，即使是没有易感因素的年轻患者，出于安全考虑，在喹硫平治疗开始时也应密切监测不良反应。
