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苏格兰急性闭角型青光眼的发病率:一项前瞻性监测研究。

The incidence of acute angle closure in Scotland: a prospective surveillance study.

作者信息

Chua Paul Y, Day Alexander C, Lai Ken L, Hall Nikki, Tan Lai L, Khan Kamran, Lim Lik Thai, Foot Barny, Foster Paul J, Azuara-Blanco Augusto

机构信息

Department of Ophthalmology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.

The NIHR Biomedical Research Centre, Moorfields Eye Hospital, NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.

出版信息

Br J Ophthalmol. 2018 Apr;102(4):539-543. doi: 10.1136/bjophthalmol-2017-310725. Epub 2017 Aug 9.

Abstract

PURPOSE

To estimate the incidence, and describe the clinical features and short-term clinical outcomes of acute angle closure (AAC).

METHODS

Patients with newly diagnosed AAC were identified prospectively over a 12-month period (November 2011 to October 2012) by active surveillance through the Scottish Ophthalmic Surveillance Unit reporting system. Data were collected at case identification and at 6 months follow-up.

RESULTS

There were 114 cases (108 patients) reported, giving an annual incidence of 2.2 cases (95% CI 1.8 to 2.6) or 2 patients (95% CI 1.7 to 2.4) per 1 00 000 in the whole population in Scotland. Precipitating factors were identified in 40% of cases. Almost one in five cases was associated with topical dilating drops. Best-corrected visual acuity (BCVA) at presentation ranged from 6/6 to perception of light. The mean presenting intraocular pressure (IOP) was 52 mm Hg (SD 11). Almost 30% cases had a delayed presentation of 3 or more days. At 6 months follow-up, 75% had BCVA of 6/12 or better and 30% were found to have glaucoma at follow-up. Delayed presentation (≥3 days) was associated with higher rate of glaucoma at follow-up (22.6% vs 60.8%, p<0.001), worse VA (0.34 vs 0.74 LogMAR, p<0.0001) and need for more topical medication (0.52 vs 1.2, p=0.003) to control IOP.

CONCLUSION

The incidence of AAC in Scotland is relatively low compared with the Far East countries, but in line with previous European data. Almost one in five cases were associated with pupil dilation for retinal examination.

摘要

目的

评估急性闭角型青光眼(AAC)的发病率,描述其临床特征及短期临床结局。

方法

通过苏格兰眼科监测单位报告系统进行主动监测,前瞻性地确定2011年11月至2012年10月这12个月期间新诊断的AAC患者。在病例确诊时及随访6个月时收集数据。

结果

共报告114例(108名患者),苏格兰总人口中每年发病率为2.2例(95%可信区间1.8至2.6)或每100,000人中有2例(95%可信区间1.7至2.4)。40%的病例确定了诱发因素。近五分之一的病例与局部散瞳滴眼液有关。就诊时最佳矫正视力(BCVA)范围从6/6至光感。就诊时平均眼压(IOP)为52 mmHg(标准差11)。近30%的病例就诊延迟3天或更长时间。在随访6个月时,75%的患者BCVA为6/12或更好,30%的患者在随访时被发现患有青光眼。就诊延迟(≥3天)与随访时青光眼发生率较高(22.6%对60.8%,p<0.001)、视力较差(0.34对0.74 LogMAR,p<0.0001)以及控制眼压所需更多局部用药(0.52对1.2,p = 0.003)相关。

结论

与远东国家相比,苏格兰AAC的发病率相对较低,但与先前欧洲数据一致。近五分之一的病例与视网膜检查散瞳有关。

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