Tariq Sohaib, Shallwani Hussain, Waqas Muhammad, Bari Muhammad Ehsan
Section of Neurosurgery, The Aga Khan University Hospital, Karachi, Pakistan.
Ann Med Surg (Lond). 2017 Jul 19;21:93-95. doi: 10.1016/j.amsu.2017.07.042. eCollection 2017 Sep.
Congenital and infantile malignant melanomas are rare and typically carry poor prognosis. The purpose of this article was to review the data on congenital and infantile malignant melanomas of the scalp in order to understand its presentation, diagnosis, management, and outcomes of congenital melanoma of scalp. We searched PubMed, CINAHL and Cochrane databases. Ten cases of congenital and 3 cases of infantile malignant melanoma of scalp were identified. The diagnosis was confirmed by biopsy and histological analysis for confirmation. The prognosis depends on the origin of disease (congenital melanocytic nevus, transplacental metastasis, or de-novo), tumor thickness, the presence of ulceration and/or necrosis, and anatomic site (scalp lesions having poor prognosis). The most commonly used treatment of the reported cases of congenital and infantile melanoma was surgical excision of the primary lesion. Further modes of treatment may be extrapolated from the treatment of childhood and adult melanomas.
先天性和婴儿期恶性黑色素瘤较为罕见，通常预后较差。本文旨在回顾有关头皮先天性和婴儿期恶性黑色素瘤的数据，以便了解其临床表现、诊断、治疗及头皮先天性黑色素瘤的预后情况。我们检索了PubMed、CINAHL和Cochrane数据库。共确定了10例先天性头皮恶性黑色素瘤病例和3例婴儿期头皮恶性黑色素瘤病例。诊断通过活检和组织学分析得以证实。预后取决于疾病的起源（先天性黑素细胞痣、经胎盘转移或新发）、肿瘤厚度、溃疡和/或坏死的存在情况以及解剖部位（头皮病变预后较差）。所报道的先天性和婴儿期黑色素瘤病例最常用的治疗方法是手术切除原发灶。进一步的治疗方式可从儿童和成人黑色素瘤的治疗方法中推断得出。
