果蝇自闭症谱系障碍研究。
Drosophila Studies on Autism Spectrum Disorders.
机构信息
Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, China.
出版信息
Neurosci Bull. 2017 Dec;33(6):737-746. doi: 10.1007/s12264-017-0166-6. Epub 2017 Aug 9.
Abstract
In the past decade, numerous genes associated with autism spectrum disorders (ASDs) have been identified. These genes encode key regulators of synaptogenesis, synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.
摘要
在过去的十年中，已经发现了许多与自闭症谱系障碍（ASD）相关的基因。这些基因编码了突触发生、突触功能和突触可塑性的关键调节因子。果蝇是 ASD 研究的重要模型系统，用于定义与 ASD 相关的新基因，并阐明它们在突触发生、突触功能、突触可塑性以及神经回路组装和巩固中的分子作用。在这里，我们综述了通过调节染色质重塑、转录、蛋白质合成和降解、细胞骨架动态和突触支架来调节突触发生、突触功能和突触可塑性的果蝇 ASD 基因研究。
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