Motohashi Ryosuke, Noma Hidetaka, Yasuda Kanako, Kotake Osamu, Goto Hiroshi, Shimura Masahiko
Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
Ophthalmic Res. 2017;58(4):209-216. doi: 10.1159/000478705. Epub 2017 Aug 11.
To evaluate the dynamic changes of the aqueous humor levels of inflammatory factors between patients receiving intravitreal ranibizumab injection (IRI) and aflibercept injection (IAI) in patients with exudative age-related macular degeneration (AMD).
The study was performed on 30 eyes with AMD that were scheduled to receive 3 doses of IRI (15 eyes) or IAI (15 eyes) at monthly intervals. Aqueous humor samples were collected when injection was done. The concentrations of VEGF, monocyte chemoattractant protein 1 (MCP-1), platelet-derived growth factor (PDGF)-AA, interleukin (IL)-6, and IL-8 were measured in aqueous humor samples from the 30 AMD patients and 10 cataract patients (as controls) by the suspension array method.
Aqueous levels of the inflammatory factors (MCP-1, PDGF-AA, IL-6, and IL-8) were significantly correlated with each other. In both the IRI-treated eyes and the IAI-treated eyes, visual acuity and central macular thickness improved significantly, and the aqueous level of VEGF showed a significant decrease. In IAI-treated eyes, the aqueous levels of MCP-1 and PDGF-AA were significantly decreased at 2 months.
These findings suggest that the inflammatory factors are involved in the pathogenesis of AMD and also the possibility that the interaction between these inflammatory factors and IRI or IAI is different.
评估玻璃体内注射雷珠单抗（IRI）和阿柏西普注射（IAI）的渗出性年龄相关性黄斑变性（AMD）患者房水中炎症因子水平的动态变化。
对30只患AMD的眼睛进行研究，这些眼睛计划每月接受3剂IRI（15只眼）或IAI（15只眼）。在注射时采集房水样本。通过悬浮阵列法测量30例AMD患者和10例白内障患者（作为对照）房水样本中血管内皮生长因子（VEGF）、单核细胞趋化蛋白1（MCP-1）、血小板衍生生长因子（PDGF）-AA、白细胞介素（IL）-6和IL-8的浓度。
炎症因子（MCP-1、PDGF-AA、IL-6和IL-8）的房水水平彼此显著相关。在接受IRI治疗的眼睛和接受IAI治疗的眼睛中，视力和中心黄斑厚度均显著改善，且VEGF的房水水平显著降低。在接受IAI治疗的眼睛中，MCP-1和PDGF-AA的房水水平在2个月时显著降低。
这些发现表明炎症因子参与了AMD的发病机制，并且这些炎症因子与IRI或IAI之间相互作用存在差异的可能性。
