a Agilent Technologies , Santa Clara , CA , USA.
Pharm Dev Technol. 2018 Mar;23(3):247-254. doi: 10.1080/10837450.2017.1365370. Epub 2017 Aug 24.
In this study, we investigated the elemental impurities present in the plastic material of ophthalmic eye drop bottles using inductively coupled plasma-mass spectrometry (ICP-MS). Metallic contaminations, especially localized within the small cavity of the eye, can significantly perturb the ocular metallome. The concern is two-fold: first certain elements, for example heavy metals, can be toxic to humans at even trace levels, and second, these contaminations can have adverse reactions with other medicines or enzymatic processes in the eye. The implication of redox-active metals in cataract formation is one such biological consequence. The analysis demonstrated the effect of aggressive storage and transportation conditions on elemental extractable and leachable contamination, and posits that release of these elemental impurities can disrupt metallome equilibrium in the ocular compartment, leading to toxicity and disease.
在这项研究中，我们使用电感耦合等离子体质谱法（ICP-MS）研究了眼药水瓶塑料材料中存在的元素杂质。金属污染物，特别是在眼睛的小腔室内局部存在，会显著扰乱眼内金属组。这有两方面的担忧：首先，某些元素，例如重金属，即使在痕量水平也可能对人类有毒，其次，这些污染物可能与眼睛中的其他药物或酶反应产生不良反应。活性金属在白内障形成中的作用就是这样一个生物学后果。分析表明，恶劣的储存和运输条件会对可萃取和可浸出的元素杂质产生影响，并假设这些元素杂质的释放会破坏眼部金属组的平衡，导致毒性和疾病。
