阿奇罗二聚体F，一种来自澳大利亚丝膜菌科真菌的酪氨酰-DNA磷酸二酯酶I抑制剂。
Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae.
作者信息
Tian Li-Wen, Feng Yunjiang, Tran Trong D, Shimizu Yoko, Pfeifer Tom, Vu Hoan T, Quinn Ronald J
机构信息
Griffith Institute for Drug Discovery, Griffith University, Brisbane QLD 4111, Australia.
Centre for Drug Research and Development, Vancouver, British Columbia V6T1Z3, Canada.
出版信息
Bioorg Med Chem Lett. 2017 Sep 1;27(17):4007-4010. doi: 10.1016/j.bmcl.2017.07.062. Epub 2017 Jul 24.
Mass-guided isolation of the dichloromethane/methanol extracts from a specimen of teleomorphic fungus of the family Cortinariaceae resulted in the identification of a new dimeric cyclobutane metabolite, achyrodimer F (1), along with the monomers hispidin (2) and bisnoryangonin (3). Their structures were determined by NMR and MS data analyses. Density Function Theory (DFT) NMR calculations was employed to confirm the chemical structure of achyrodimer F. Compound 1 inhibited tyrosyl-DNA phosphodiesterase I with an IC value of 1μM.
通过对丝膜菌科一种有性态真菌标本的二氯甲烷/甲醇提取物进行大规模引导分离，鉴定出一种新的二聚体环丁烷代谢产物——achyrodimer F（1），以及单体漆斑菌素（2）和双去甲姜黄酮（3）。通过核磁共振（NMR）和质谱（MS）数据分析确定了它们的结构。采用密度泛函理论（DFT）核磁共振计算来确认achyrodimer F的化学结构。化合物1对酪氨酰-DNA磷酸二酯酶I具有抑制作用，IC值为1μM。
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