Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Department of Breast Oncology, National Cancer Center/Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
J Cell Mol Med. 2018 Jan;22(1):123-130. doi: 10.1111/jcmm.13300. Epub 2017 Aug 10.
The most common forms of oesophageal cancers are adenocarcinomas and squamous cell carcinoma (SCC). Although the incidence of SCC in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with PCNSL keep backward in spite of recent development of chemoradiotherapy. MicroRNAs are small non-coding RNAs that can post-transcriptionally down-regulate the expression of genes by targeting mRNAs, causing their translational repression as well as degradation. MicroRNAs exert critical functions in many malignancy-related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated miRNAs have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated microRNAs for prognosis and diagnosis of this lethal disease.
最常见的食管癌类型为腺癌和鳞状细胞癌（SCC）。虽然 SCC 在 美国的发病率呈下降趋势，但 Barrett 食管引起的腺癌发病率一直在上升。食管癌被认为是预后最差的最致命恶性肿瘤之一。尽管最近开展了放化疗，但原发性中枢神经系统淋巴瘤患者的全身表现仍在不断恶化。微小 RNA 是一种小的非编码 RNA，可以通过靶向 mRNAs 来转录后下调基因的表达，从而导致其翻译抑制和降解。微小 RNA 在许多与恶性肿瘤相关的生物学过程中发挥着关键作用，包括细胞凋亡、代谢、增殖和分化。在食管腺癌中已经发现了许多失调的微小 RNA，但它们的生物学重要性尚未完全阐明。在本研究中，我们回顾了与食管腺癌相关微小 RNA 用于该致命疾病的预后和诊断的潜在应用的现有证据。
