新发每日持续性头痛患者中EB病毒排泄频率增加。

Increased frequency of Epstein-Barr virus excretion in patients with new daily persistent headaches.

作者信息

Diaz-Mitoma F, Vanast W J, Tyrrell D L

出版信息

Lancet. 1987 Feb 21;1(8530):411-5. doi: 10.1016/s0140-6736(87)90119-x.

Abstract

In a case-control study 27 (84%) of 32 patients with new daily persistent headaches (NDPH) and 8 (25%) of 32 controls had evidence of Epstein-Barr virus (EBV) "active" infection, as demonstrated by EBV excretion and/or early antigen titre above 1:32. 20 (62%) patients and 4 (12%) controls were excreting EBV in the oropharynx, as determined by a dot hybridisation assay. The mean titre of IgG antibodies to early antigen was significantly higher in patients than controls. EBV reactivation may be important in the pathogenesis of NDPH. Alternatively, patients with NDPH may be unusually prone to EBV reactivation.

摘要

在一项病例对照研究中，32例新发性每日持续性头痛（NDPH）患者中有27例（84%），32例对照中有8例（25%）有EB病毒（EBV）“活动性”感染的证据，表现为EBV排泄和/或早期抗原滴度高于1:32。通过斑点杂交试验测定，20例（62%）患者和4例（12%）对照在口咽中排泄EBV。患者中针对早期抗原的IgG抗体平均滴度显著高于对照。EBV再激活可能在NDPH的发病机制中起重要作用。或者，NDPH患者可能异常容易发生EBV再激活。