Curnow Jennifer
Departments of Clinical and Laboratory Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.
Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, 170 Hawkesbury Rd., Westmead, NSW, 2145, Australia.
Methods Mol Biol. 2017;1646:523-531. doi: 10.1007/978-1-4939-7196-1_38.
The principle of the overall hemostatic potential (OHP) assay is the generation of a fibrin time curve by optical density readings, which represent the balance between fibrin generation, triggered by thrombin or tissue factor, and fibrinolysis, triggered by tissue plasminogen activator (tPA). OHP measures the integrated effect of procoagulant, anticoagulant, and fibrinolytic factors, and OHP assay parameters provide a means of quantifying both the coagulation and fibrinolytic potential of platelet poor plasma. In particular, the OHP assay can be used to evaluate hypercoagulable states and abnormalities of fibrinolysis which are not well defined by assays which are routinely available in the coagulation laboratory. OHP is a technically simple assay, with potential for application in the routine laboratory at minimal cost.
整体止血潜能（OHP）测定的原理是通过光密度读数生成纤维蛋白时间曲线，该曲线代表由凝血酶或组织因子触发的纤维蛋白生成与由组织纤溶酶原激活物（tPA）触发的纤维蛋白溶解之间的平衡。OHP测量促凝血、抗凝血和纤维蛋白溶解因子的综合作用，OHP测定参数提供了一种量化乏血小板血浆凝血和纤维蛋白溶解潜能的方法。特别是，OHP测定可用于评估高凝状态和纤维蛋白溶解异常，而这些在凝血实验室常规可用的检测方法中并未得到很好的定义。OHP是一种技术上简单的检测方法，有可能以最低成本应用于常规实验室。
