小儿骨肉瘤和尤文肉瘤恶性骨肿瘤化疗治疗反应的定量扩散加权磁共振成像评估
Quantitative diffusion-weighted magnetic resonance imaging assessment of chemotherapy treatment response of pediatric osteosarcoma and Ewing sarcoma malignant bone tumors.
作者信息
Degnan Andrew J, Chung Chul Y, Shah Amisha J
机构信息
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States.
出版信息
Clin Imaging. 2018 Jan-Feb;47:9-13. doi: 10.1016/j.clinimag.2017.08.003. Epub 2017 Aug 5.
OBJECTIVE
Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection.
SUBJECTS AND METHODS
Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers.
RESULTS
Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment.
CONCLUSIONS
Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
目的
在切除恶性小儿骨肿瘤之前，评估肿瘤对化疗的反应对于治疗管理至关重要。
对象与方法
对18例化疗前和化疗后的骨肉瘤及尤文肉瘤病例，由两位阅片者测量表观扩散系数（ADC）值进行分析。
结果
与未治疗的肿瘤相比，接受治疗的肿瘤显示出明显更高的ADC值（p<0.001）。组内相关系数在0.858至0.935之间。未观察到明显的肿瘤体积差异。回归分析表明平均ADC是治疗效果的最佳预测指标。
结论
我们的研究表明，ADC值可能有助于评估恶性小儿骨肿瘤的化疗反应。
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