Wood Sossena, Krishnamurthy Narayanan, Santini Tales, Raval Shailesh B, Farhat Nadim, Holmes John Andy, Ibrahim Tamer S
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Swanson Center for Product Innovation, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
PLoS One. 2017 Aug 14;12(8):e0183168. doi: 10.1371/journal.pone.0183168. eCollection 2017.
The purpose of this study is to design an anthropomorphic heterogeneous head phantom that can be used for MRI and other electromagnetic applications.
An eight compartment, physical anthropomorphic head phantom was developed from a 3T MRI dataset of a healthy male. The designed phantom was successfully built and preliminarily evaluated through an application that involves electromagnetic-tissue interactions: MRI (due to it being an available resource). The developed phantom was filled with media possessing electromagnetic constitutive parameters that correspond to biological tissues at ~297 MHz. A preliminary comparison between an in-vivo human volunteer (based on whom the anthropomorphic head phantom was created) and various phantoms types, one being the anthropomorphic heterogeneous head phantom, were performed using a 7 Tesla human MRI scanner.
Echo planar imaging was performed and minimal ghosting and fluctuations were observed using the proposed anthropomorphic phantom. The magnetic field distributions (during MRI experiments at 7 Tesla) and the scattering parameter (measured using a network analyzer) were most comparable between the anthropomorphic heterogeneous head phantom and an in-vivo human volunteer.
The developed anthropomorphic heterogeneous head phantom can be used as a resource to various researchers in applications that involve electromagnetic-biological tissue interactions such as MRI.
本研究的目的是设计一种可用于磁共振成像(MRI)和其他电磁应用的拟人化异质头部模型。
从一名健康男性的3T MRI数据集开发了一个八腔室的物理拟人化头部模型。通过一个涉及电磁-组织相互作用的应用(由于MRI是一种可用资源),成功构建了设计的模型并进行了初步评估。所开发的模型填充了具有与~297 MHz生物组织相对应的电磁本构参数的介质。使用7特斯拉人体MRI扫描仪对一名活体人类志愿者(基于其创建了拟人化头部模型)与各种模型类型(其中一种是拟人化异质头部模型)进行了初步比较。
使用所提出的拟人化模型进行了回波平面成像,观察到最小的重影和波动。在7特斯拉的MRI实验期间,拟人化异质头部模型与活体人类志愿者之间的磁场分布和散射参数(使用网络分析仪测量)最具可比性。
所开发的拟人化异质头部模型可作为一种资源供各类研究人员用于涉及电磁-生物组织相互作用(如MRI)的应用中。