Ishihara Masahiro, Yamamoto Kazumi, Miwa Hideaki, Nishi Masaya
Department of Neurosurgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai City, Osaka, 591-8025, Japan.
Department of Pathology, Osaka Rosai Hospital, Sakai City, Osaka, Japan.
Childs Nerv Syst. 2017 Dec;33(12):2177-2180. doi: 10.1007/s00381-017-3570-3. Epub 2017 Aug 14.
Spontaneous regressions of brain stem gliomas are extremely rare. Only six cases have been reported in the literature.
We describe the case of a patient who was diagnosed with a pontomedullary dorsal brain stem glioma at the age of 15 years. An open biopsy showed the presence of an anaplastic glioma. Because the patient and her parents refused conventional therapies, including radiation and chemotherapy, we followed up the patient by performing magnetic resonance imaging scans on her every 3 months. At 3 months after biopsy, we observed the radiological disappearance of her tumor. One year after biopsy, the tumor retained the spontaneous complete regression observed earlier.
In this case report, we present the first report of the spontaneous complete regression of a brain stem glioma that was histologically proven to be a high-grade glioma and we believe that this regression was the natural progression of this case, as may be the scenario in a few other cases of brain stem gliomas.
脑干胶质瘤的自发消退极为罕见。文献中仅报道过6例。
我们描述了一名15岁被诊断为脑桥延髓背侧脑干胶质瘤的患者。开放活检显示为间变性胶质瘤。由于患者及其父母拒绝包括放疗和化疗在内的传统治疗，我们每3个月对患者进行一次磁共振成像扫描以进行随访。活检后3个月，我们观察到肿瘤在影像学上消失。活检后1年，肿瘤保持了早期观察到的自发完全消退。
在本病例报告中，我们首次报告了组织学证实为高级别胶质瘤的脑干胶质瘤自发完全消退的情况，我们认为这种消退是该病例的自然病程，其他一些脑干胶质瘤病例可能也是如此。
