School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212013, China; Department of Applied Biology & Chemical Technology, State Key Laboratory of Chinese Medicine and Molecular Pharmacology in Shenzhen, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
Carbohydr Polym. 2017 Oct 15;174:209-216. doi: 10.1016/j.carbpol.2017.06.082. Epub 2017 Jun 23.
In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construct nanosized polyelectrolyte complexes (PECs) with a polycation, chitosan (CS), via electrostatic interactions. Nanosized PECs were formed simply by mixing CRDS (0.5mg/mL) and CS (0.5mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180nm and a zeta potential value of about -38mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.
在这项研究中，选择合成的硫酸葡聚糖（CRDS）作为带柔性无规线团链的聚阴离子，通过静电相互作用与聚阳离子壳聚糖（CS）构建纳米级聚电解质复合物（PECs）。通过在 pH 值为 3.5 时将 CRDS（0.5mg/mL）和 CS（0.5mg/mL）以质量比 2:1 简单混合，形成纳米级 PECs。CRDS/CS PECs 呈球形形态，Z 均直径约为 180nm，zeta 电位值约为-38mV。随后，将齐多夫定（AZT）作为模型抗病毒药物成功包封到纳米级 PECs 中，具有良好的载药效率。载药 PECs 呈现出受 pH 值控制的 AZT 释放特性。这些发现表明，本研究中构建的 CRDS/CS PECs 可开发为用于药物递送应用的潜在纳米载体。
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