Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX 77005, USA.
Lab Chip. 2017 Oct 11;17(20):3351-3387. doi: 10.1039/c7lc00374a.
Each day, approximately 830 women and 7400 newborns die from complications during pregnancy and childbirth. Improving maternal and neonatal health will require bringing rapid diagnosis and treatment to the point of care in low-resource settings. However, to date there are few diagnostic tools available that can be used at the point of care to detect the leading causes of maternal and neonatal mortality in low-resource settings. Here we review both commercially available diagnostics and technologies that are currently in development to detect the leading causes of maternal and neonatal mortality, highlighting key gaps in development where innovative design could increase access to technology and enable rapid diagnosis at the bedside.
每天,约有 830 名妇女和 7400 名新生儿死于妊娠和分娩期间的并发症。改善孕产妇和新生儿健康状况需要将快速诊断和治疗带到资源匮乏环境中的护理点。然而,迄今为止,几乎没有可以在护理点用于检测资源匮乏环境中孕产妇和新生儿死亡主要原因的诊断工具。在这里,我们回顾了目前可用于检测孕产妇和新生儿死亡主要原因的商业上可用的诊断方法和技术,强调了在开发过程中的关键差距,在这些差距中,创新设计可以增加对技术的获取,并使床边快速诊断成为可能。