Job J C, Joab N, Safar A, Canlorbe P
Arch Fr Pediatr. 1987 Feb;44(2):91-5.
93 cryptorchid boys aged 1 to 6 years were treated with nasal spray of LHRH according with two different protocols: 0.4 mg thrice daily during 28 consecutive days in 39 (32 uni and 7 bilaterally cryptorchid) and 0.4 mg twice daily on alternate days three days per week for 1 month in 32 and 3 months in 22 (34 uni and 20 bilaterally cryptorchid). The results did not vary according to age or to the protocol and duration of treatment. Complete testicular descent was obtained for only 10% of unilaterally undescended testes, and reached 29% in bilaterally undescended testes. These results do not relate to the more or less high position of the testis nor to hypothetical changes in plasma gonadotropins or testosterone. The treatment had very minor side-effects. For this reason, in spite of its very limited results, it may be used either as an attempt before surgery at 4-6 years or as a means to distinguish retractile from undescended testes.
93名年龄在1至6岁的隐睾男孩按照两种不同方案接受了促黄体生成素释放激素(LHRH)鼻喷雾剂治疗:39名(32名单侧隐睾和7名双侧隐睾)连续28天每日三次使用0.4毫克;32名隔日每日两次、每周三天,持续1个月,22名持续3个月(34名单侧隐睾和20名双侧隐睾),每次0.4毫克。结果并未因年龄、治疗方案及疗程而异。单侧隐睾仅有10%实现睾丸完全下降,双侧隐睾则达到29%。这些结果与睾丸位置高低及血浆促性腺激素或睾酮的假定变化无关。该治疗的副作用非常轻微。因此,尽管效果非常有限,但它既可以在4至6岁手术前尝试使用,也可作为区分回缩性睾丸与隐睾的一种方法。