[Biotransformation and pharmacokinetics of bamipine in rats. 2. Studies of the pharmacokinetics (1.)].

Biotransformation and Pharmacokinetics of Bamipine in Rats/2nd Communication: Pharmacokinetic studies (Part I). After oral application in Wistar rats the pharmacokinetic properties of N-phenyl-N-benzyl-4-amino-1-methylpiperidine (bamipine) were investigated. The compound is quantitatively absorbed. Bamipine distribution occurs in the whole organism. A transient accumulation was found in liver, kidney, spleen and lung. The compound's liquor patency was established. The elimination is mainly renal (85.81%), 13.23% are eliminated by feces. The total excretion after 96 h is more than 99%.