多形性胶质母细胞瘤复发后的再照射
Re-irradiation for recurrent glioblastoma multiforme.
作者信息
Barney Christian, Shukla Gaurav, Bhamidipati Deepak, Palmer Joshua D
机构信息
Department of Radiation Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pa, USA.
出版信息
Chin Clin Oncol. 2017 Aug;6(4):36. doi: 10.21037/cco.2017.06.18.
As our understanding of normal brain tissue tolerance and radiation technology have improved, central nervous system (CNS) re-irradiation has garnered more attention; whereas, in the past there had been hesitancy due to late toxicity concerns, particularly radionecrosis (RN). There is minimal prospective data evaluating repeat radiation in recurrent gliomas. In this review, the rationale for and different approaches to re-irradiation will be discussed, and the biology and clinical impact of late CNS toxicity will be reviewed.
随着我们对正常脑组织耐受性和放射技术的理解不断提高，中枢神经系统（CNS）再程放疗已受到更多关注；而在过去，由于对晚期毒性尤其是放射性坏死（RN）的担忧，一直存在犹豫。评估复发性胶质瘤重复放疗的前瞻性数据极少。在本综述中，将讨论再程放疗的原理和不同方法，并回顾晚期中枢神经系统毒性的生物学和临床影响。
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