Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, 79409, USA; Department of Bionanotechnology, Gachon University, Seongnam-Si, 461-701, Republic of Korea.
Department of Bionanotechnology, Gachon University, Seongnam-Si, 461-701, Republic of Korea.
Anal Chim Acta. 2017 Sep 1;984:168-176. doi: 10.1016/j.aca.2017.06.036. Epub 2017 Jun 30.
Smartphones and related accessories are rapidly expanding their applications in various fields. Herein we developed a smartphone coupled handheld array reader with the integration of complementary metal oxide (CMOS) image sensor for detecting various toxic gases by colorimetric monitoring approach. In this study, toxic gases such as hydrogen fluoride (HF), chlorine (Cl), ammonia (NH), and formaldehyde (CHO) were detected using titanium nanoparticles (TiO NPs) blended poly (vinyl alcohol) (PVA) hydrogel test strips, which were patterned with chemically responsive dyes. The dye colors changed based on acid-base reactions, and the colorimetric reader monitored the array strips and mapped them in the form of chrominance data. The observed signals transferred to a smartphone that displays the detected toxic gases and their exposure levels with the aid of the smartphone app "Toxic Gas Detection". The colorimetric array reader was precisely constructed with an auto-calibration system to minimize potential errors. Various concentration of toxic gases (0.5-10 ppm) were analyzed and achieved the detection limit of 1 ppm for each gas. Also, various analytical performance including sensitivity, stability, selectivity, and reproducibility analysis proved the reliability and accuracy of the detection system. Additionally, the smartphone app can be installed on any type of tablet, laptop, or other portable device. This study proved that smartphone coupled colorimetric array reader is a suitable system for detecting various toxic gases, chemicals and biochemical analysis with real-time monitoring approach.
智能手机及其相关配件正在迅速扩展其在各个领域的应用。在此，我们开发了一种智能手机耦合手持阵列读取器，该读取器集成互补金属氧化物（CMOS）图像传感器，通过比色监测方法检测各种有毒气体。在这项研究中，使用掺钛纳米粒子（TiO NPs）的聚（乙烯醇）（PVA）水凝胶测试条检测了有毒气体，如氟化氢（HF）、氯气（Cl）、氨（NH）和甲醛（CHO），这些测试条带有化学响应染料。染料颜色根据酸碱反应发生变化，比色读取器监测阵列条，并以色度数据的形式对其进行映射。观察到的信号被转移到智能手机上，智能手机借助“有毒气体检测”应用程序显示检测到的有毒气体及其暴露水平。比色阵列读取器经过精确构建，具有自动校准系统，以最大程度地减少潜在误差。分析了各种浓度的有毒气体（0.5-10 ppm），并实现了每种气体 1 ppm 的检测限。此外，各种分析性能，包括灵敏度、稳定性、选择性和重现性分析，证明了检测系统的可靠性和准确性。此外，智能手机应用程序可以安装在任何类型的平板电脑、笔记本电脑或其他便携式设备上。本研究证明，智能手机耦合比色阵列读取器是一种适用于实时监测方法检测各种有毒气体、化学物质和生物化学分析的系统。
