子痫前期重度患者的苯妥英钠输注

Phenytoin infusion in severe pre-eclampsia.

作者信息

Slater R M, Wilcox F L, Smith W D, Donnai P, Patrick J, Richardson T, Mawer G E, D'Souza S W, Anderton J M

出版信息

Lancet. 1987 Jun 20;1(8547):1417-21. doi: 10.1016/s0140-6736(87)90603-9.

Abstract

Intravenous phenytoin sodium was given as a high-dose infusion (10 X 8-18 mg/kg) for anticonvulsive prophylaxis to 2 eclamptic patients and to 24 patients with moderate to severe pre-eclampsia. There were no major maternal or neonatal side-effects. Plasma phenytoin levels were within the therapeutic range (7-20 mg/l) at 30 min and 6 h after the infusion in all patients, and remained at a therapeutic level in 21 patients after 12 h. After a second dose of phenytoin in 19 patients, drug levels were within the therapeutic range at 24 h.

摘要

对2例子痫患者和24例中重度先兆子痫患者静脉注射大剂量苯妥英钠（10×8 - 18mg/kg）进行抗惊厥预防。未出现严重的母体或新生儿副作用。所有患者在输注后30分钟和6小时时血浆苯妥英水平均在治疗范围内（7 - 20mg/l），21例患者在12小时后仍维持在治疗水平。19例患者接受第二剂苯妥英后，24小时时药物水平在治疗范围内。