三肽在体外模拟阿尔茨海默病条件下可恢复神经元棘突数量。

Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease.

作者信息

Kraskovskaya N A, Kukanova E O, Lin'kova N S, Popugaeva E A, Khavinson V Kh

机构信息

Peter the Great Saint Petersburg Polytechnic University, St. Petersburg, Russia.

St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.

出版信息

Bull Exp Biol Med. 2017 Aug;163(4):550-553. doi: 10.1007/s10517-017-3847-2. Epub 2017 Aug 29.

DOI:10.1007/s10517-017-3847-2

PMID:28853087

Abstract

In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer's disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer's disease.

摘要

在小鼠海马神经元的原代培养中，在淀粉样突触毒性（阿尔茨海默病模型）条件下，肽EDR（200 ng/ml）使蘑菇状棘突的数量增加了71%，并使该参数恢复到正常水平。在相同条件下，三肽KED（200 ng/ml）使海马神经元中蘑菇状棘突的数量增加了20%。三肽EDR作为预防和治疗阿尔茨海默病的候选神经保护剂，可推荐用于进一步的实验研究。