与骨髓炎相比，2期药物相关性颌骨坏死的外科治疗
Surgical treatment of stage 2 medication-related osteonecrosis of the jaw compared to osteomyelitis.
作者信息
Kang Sang-Hoon, Won Yu-Jin, Kim Moon-Key
机构信息
a Department of Oral and Maxillofacial Surgery , National Health Insurance Service Ilsan Hospital , Goyang , Republic of Korea.
b Department of Oral and Maxillofacial Surgery, College of Dentistry , Yonsei University , Seoul , Republic of Korea.
出版信息
Cranio. 2018 Nov;36(6):373-380. doi: 10.1080/08869634.2017.1365413. Epub 2017 Aug 30.
OBJECTIVE
To compare the characteristics and outcomes of patients who underwent surgical treatment for stage 2 medication-related osteonecrosis of the jaw (MRONJ) versus osteomyelitis.
METHODS
This retrospective study compared the following variables in 73 patients with stage 2 MRONJ versus 89 patients with osteomyelitis: impaired wound healing after surgery, sex, age, the presence of actinomycosis, location of the jaw lesion, and involvement of the inferior alveolar nerve (IAN).
RESULTS
There were significant differences between the groups in age, sex, rates of impaired wound healing, actinomycosis, and the location (anterior/posterior) of the lesion. Impaired wound healing after surgical treatment in the stage 2 MRONJ group was associated with patient age. All patients with impaired wound healing after the initial surgery recovered fully after reoperation.
CONCLUSIONS
These findings for surgical treatment of stage 2 MRONJ may help clinicians plan surgical treatment of MRONJ.
目的
比较接受手术治疗的2期药物相关性颌骨坏死（MRONJ）患者与骨髓炎患者的特征及治疗结果。
方法
这项回顾性研究比较了73例2期MRONJ患者和89例骨髓炎患者的以下变量：术后伤口愈合受损情况、性别、年龄、放线菌病的存在情况、颌骨病变位置以及下牙槽神经（IAN）受累情况。
结果
两组在年龄、性别、伤口愈合受损率、放线菌病以及病变位置（前部/后部）方面存在显著差异。2期MRONJ组手术治疗后伤口愈合受损与患者年龄有关。初次手术后所有伤口愈合受损的患者再次手术后均完全康复。
结论
这些关于2期MRONJ手术治疗的研究结果可能有助于临床医生规划MRONJ的手术治疗。
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