Benner Seico, Yamasue Hidenori
Department of Neuropsychiatry, School of Medicine, The University of Tokyo, Tokyo.
Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Behav Pharmacol. 2018 Feb;29(1):1-12. doi: 10.1097/FBP.0000000000000341.
The effects of oxytocin on social cognition and behavior have recently attracted considerable attention. In particular, oxytocin has been proposed as a novel therapeutic for psychiatric disorders with social deficits such as autism spectrum disorders. This review provides a brief overview of behavioral and neural responses to oxytocin manipulations in humans and animal models. Although the differences in findings between human and animal studies should be interpreted carefully, shared behavioral phenotypes have been recognized, such as social bonding, social responses, and recognition and usage of social cues. Previous literature suggests that the neural effects of oxytocin in humans and animals overlap in the prefrontal, limbic, and paralimbic cortices. Oxytocin-induced alterations in these regions may indicate a fundamental basis for how oxytocin modulates social behaviors and facilitate the discovery of new pharmaceutical targets for treating social deficits.
催产素对社会认知和行为的影响最近引起了相当大的关注。特别是，催产素已被提议作为治疗自闭症谱系障碍等具有社交缺陷的精神疾病的一种新型疗法。本综述简要概述了人类和动物模型中对催产素操纵的行为和神经反应。尽管人类和动物研究结果的差异应谨慎解释，但已识别出共同的行为表型，如社会联结、社会反应以及社会线索的识别和运用。先前的文献表明，催产素在人类和动物中的神经效应在前额叶、边缘叶和边缘旁叶皮质中存在重叠。这些区域中催产素诱导的变化可能表明催产素调节社会行为以及促进发现治疗社交缺陷新药物靶点的基本机制。
