三氧化二砷对肝癌中埃兹蛋白表达的影响。

Effects of arsenic trioxide on the expression of ezrin in hepatocellular carcinoma.

作者信息

Lu Wei, Yang Chao, Du Peng, Zhang Jun-Li, Zhang Jia-Cheng

机构信息

Department of Interventional Medicine, Navy General Hospital of PLA, Beijing, China.

出版信息

Medicine (Baltimore). 2017 Sep;96(35):e7602. doi: 10.1097/MD.0000000000007602.

DOI:10.1097/MD.0000000000007602

PMID:28858082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5585476/

Abstract

The aim of the study was to investigate the effects of arsenic trioxide (As2O3) treatment on the expression of ezrin and serum alpha-fetoprotein (AFP) levels in hepatocellular carcinoma (HCC).A total of 24 patients (20 males and 4 females) with resectable HCC were treated with venous injection of As2O3 for 14 days (10 mg/d) before surgery. The ezrin expression and serum AFP levels were assessed before and after treatment, respectively.The serum AFP levels were 325.5 ng/L before treatment and 278.6 ng/L after treatment, with statistical significant difference (Z = -2.360, P < .05). The expression of ezrin was negative, weak positive, and strong positive in 11, 7, and 6 cases, respectively, before As2O3 treatment, and 17, 5, 2 cases respectively after the treatment. The difference between the 2 groups was statistically significant (χ = 5.619, P < .05). Also, the results showed that there was a significant correlation between the high serum AFP level (AFP ≥ 500 ng/L) and high expression of ezrin (χ = 8.080, P < .05).As2O3 treatment can significantly downregulate the expression of ezrin in HCC.

摘要

本研究旨在探讨三氧化二砷（As2O3）治疗对肝细胞癌（HCC）中埃兹蛋白表达及血清甲胎蛋白（AFP）水平的影响。共有24例可切除性HCC患者（20例男性，4例女性）在手术前接受静脉注射As2O3治疗14天（10毫克/天）。分别在治疗前后评估埃兹蛋白表达及血清AFP水平。治疗前血清AFP水平为325.5纳克/升，治疗后为278.6纳克/升，差异有统计学意义（Z = -2.360，P <.05）。在As2O3治疗前，埃兹蛋白表达阴性、弱阳性和强阳性分别为11例、7例和6例，治疗后分别为17例、5例和2例。两组间差异有统计学意义（χ = 5.619，P <.05）。此外，结果显示高血清AFP水平（AFP≥500纳克/升）与埃兹蛋白高表达之间存在显著相关性（χ = 8.080，P <.05）。As2O3治疗可显著下调HCC中埃兹蛋白的表达。