Hosseini Seyed Reza, Baghitabar Naghi, Mirzapour Ali, Oliaei Farshid, Nooreddini Hajighorban, Bijani Ali, Mouodi Simin
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Rom J Intern Med. 2018 Mar 1;56(1):41-46. doi: 10.1515/rjim-2017-0032.
Hyponatremia (HN) can be associated with osteoporosis, falls and bone fractures in the elderly. Recent researches demonstrated different results about the correlation of HN with bone mineral density and bone fractures.
This analytic research came from the AHAP project in northern IRAN. All people aged 60 years and over were included in the study. Individuals with severe comorbidities and then who had concurrent conditions which could have impact on bone mineral densities (BMD) such as long-term use of steroids, calcium and/or vitamin D supplements, bisphosphonates, calcitonin, thiazides and hormonal medications were excluded.
One thousand and one hundred and thirteen older persons entered in the study. More than 10 percent of the participants had HN (serum Na+ level ≤ 137mEq/L). No significant difference has been observed between hyponatremic and nonhyponatremic individuals about their balance abilities; bone mineral density; incidence of falls and/or bone fracture during the previous 6 months; dependency in activities of daily living; and osteoporosis.
HN was not a prevalent problem in older adults who met the inclusion criteria of this research. No significant difference has been observed between HN and bone mineral density and falls in the elderly.
低钠血症（HN）可能与老年人的骨质疏松症、跌倒及骨折有关。近期研究显示，关于HN与骨密度及骨折之间的相关性存在不同结果。
本分析性研究源自伊朗北部的AHAP项目。研究纳入所有60岁及以上人群。排除患有严重合并症以及患有可能影响骨密度（BMD）的并发疾病的个体，如长期使用类固醇、钙和/或维生素D补充剂、双膦酸盐、降钙素、噻嗪类药物及激素类药物的个体。
1113名老年人参与了本研究。超过10%的参与者患有HN（血清钠水平≤137mEq/L）。在平衡能力、骨密度、过去6个月内跌倒和/或骨折的发生率、日常生活活动能力依赖程度以及骨质疏松症方面，低钠血症患者与非低钠血症患者之间未观察到显著差异。
在符合本研究纳入标准的老年人中，HN并非普遍问题。在老年人中，HN与骨密度及跌倒之间未观察到显著差异。
