前列腺特异性膜抗原（PSMA）将丝裂原活化蛋白激酶（MAPK）重定向至磷脂酰肌醇-3-激酶-蛋白激酶B（PI3K-AKT）信号通路，以促进前列腺癌进展。
PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression.
作者信息
Caromile Leslie Ann, Shapiro Linda H
机构信息
Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA.
出版信息
Mol Cell Oncol. 2017 Apr 28;4(4):e1321168. doi: 10.1080/23723556.2017.1321168. eCollection 2017.
Abstract
Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-activated protein kinase-extracellular signal-regulated kinases 1 and 2 pathway to the pro-survival protein kinase B(AKT)/phosphatidylinositol 3-kinase pathway.
摘要
前列腺特异性膜抗原表达增加通过失调β1整合素/Ⅰ型胰岛素样生长因子受体轴促进前列腺上皮肿瘤进展，导致信号传导从侵袭性较小的丝裂原活化蛋白激酶-细胞外信号调节激酶1和2途径转向促生存的蛋白激酶B（AKT）/磷脂酰肌醇3激酶途径。
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