Harvey M H, Wedgwood K R, Reber H A
Surgery. 1987 Aug;102(2):229-34.
An increase in microvascular permeability may be important in the pathogenesis of acute pancreatitis. beta-adrenergic receptor agonist drugs are known to inhibit the increase in microvascular permeability induced by histamine and related vasoactive substances. These inflammatory mediators have been shown to be released during the course of experimental and human pancreatitis. We investigated the effect of isoproterenol and terbutaline sulfate on the development of acute edematous (AEP) and acute hemorrhagic (AHP) pancreatitis in a feline model of biliary pancreatitis. When given at the time of pancreatic insult, isoproterenol prevented the development of both AEP and AHP. Both isoproterenol and terbutaline sulfate reduced the severity of pancreatic inflammation, even when given up to 12 hours after the onset of AEP. Although neither drug was effective in treating established AHP, our findings suggest that, if given early in the course of the disease, they may be useful in preventing the progression of AEP to AHP.
微血管通透性增加在急性胰腺炎的发病机制中可能起重要作用。已知β-肾上腺素能受体激动剂药物可抑制组胺及相关血管活性物质诱导的微血管通透性增加。这些炎症介质已证实在实验性胰腺炎和人类胰腺炎病程中会释放。我们在猫胆汁性胰腺炎模型中研究了异丙肾上腺素和硫酸特布他林对急性水肿性胰腺炎（AEP）和急性出血性胰腺炎（AHP）发展的影响。在胰腺损伤时给予异丙肾上腺素可预防AEP和AHP的发生。异丙肾上腺素和硫酸特布他林均可减轻胰腺炎症的严重程度，即使在AEP发作后12小时给药也是如此。虽然两种药物对已确诊的AHP均无效，但我们的研究结果表明，如果在疾病早期给药，它们可能有助于预防AEP进展为AHP。
