Roy R C, Carter R F, Wright P D
Anaesthesia. 1987 Jun;42(6):627-32. doi: 10.1111/j.1365-2044.1987.tb03087.x.
A patient with carcinoid syndrome on long-term antiserotonin therapy with parachlorophenylalanine, experienced a flushing attack with hypotension during the prophylactic administration of aprotonin prior to the induction of anaesthesia. When she was subsequently prepared with a long-acting somatostatin analogue, octreotide (Sandostatin, Sandoz SMS 201-995), plasma levels of tumour-released hormones were reduced and anaesthesia for resection of hepatic metastases was uneventful. The advantages of an anaesthetic approach based on inhibition of carcinoid tumour activity, rather than antagonism of released hormones, are discussed.
一名长期使用对氯苯丙氨酸进行抗血清素治疗的类癌综合征患者，在麻醉诱导前预防性给予抑肽酶时发生了伴有低血压的潮红发作。随后当她使用长效生长抑素类似物奥曲肽（善宁，山德士SMS 201-995）进行准备时，肿瘤释放激素的血浆水平降低，肝转移瘤切除的麻醉过程顺利。本文讨论了基于抑制类癌肿瘤活性而非拮抗释放激素的麻醉方法的优点。
