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Silver Russell综合征患者正畸治疗联合双阻板矫治器治疗及生长激素治疗

Orthodontic Treatment in Conjunction with Twin-bock Treatment and Growth Hormone Therapy in Silver Russell Syndrome.

作者信息

Ko Su-Jin, Seo Ji Young, Kwon Yong-Dae, Cheon Kyounga, Park Jae Hyun

出版信息

J Clin Pediatr Dent. 2017;41(5):392-397. doi: 10.17796/1053-4628-41.5.392.

DOI:10.17796/1053-4628-41.5.392
PMID:28872989
Abstract

Silver-Russell syndrome (SRS) is a very rare genetic disorder characterized by intrauterine growth retardation, short stature, and typical craniofacial abnormalities including micrognathia. While growth hormone (GH) therapy in children with SRS significantly improves somatic growth, functional orthopedic treatment can also be effective in adolescents with mandibular deficiency. We report the effects of Phase 1 functional orthopedic treatment of a twin-block appliance in conjunction with GH administration in a 9-year-old boy with GH deficiency and SRS, and the result of the subsequent Phase 2 orthodontic treatment.

摘要

Silver-Russell综合征（SRS）是一种非常罕见的遗传性疾病，其特征为宫内生长迟缓、身材矮小以及包括小颌畸形在内的典型颅面部异常。虽然生长激素（GH）治疗可显著改善SRS患儿的躯体生长，但功能性正畸治疗对下颌骨发育不全的青少年也可能有效。我们报告了一名9岁患有生长激素缺乏症和SRS的男孩在接受第一阶段双阻板矫治器功能性正畸治疗联合生长激素给药的效果，以及随后第二阶段正畸治疗的结果。

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Orthodontic Treatment in Conjunction with Twin-bock Treatment and Growth Hormone Therapy in Silver Russell Syndrome.Silver Russell综合征患者正畸治疗联合双阻板矫治器治疗及生长激素治疗
J Clin Pediatr Dent. 2017;41(5):392-397. doi: 10.17796/1053-4628-41.5.392.
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引用本文的文献

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Silver-Russell syndrome: phenotype features and oral health status.Silver-Russell综合征：表型特征与口腔健康状况。
Orphanet J Rare Dis. 2025 Jul 19;20(1):370. doi: 10.1186/s13023-025-03886-y.