糖尿病对慢性丙型肝炎患者循环凋亡微粒的影响。
Influence of Diabetes on Circulating Apoptotic Microparticles in Patients with Chronic Hepatitis C.
作者信息
Zuwala-Jagiello Jolanta, Pazgan-Simon Monika, Murawska-Cialowicz Eugenia, Simon Krzysztof
机构信息
Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw, Poland
Infectious Disease Department, Division of Infectious Disease and Hepatology Wroclaw Medical University, Wroclaw, Poland.
出版信息
In Vivo. 2017 Sep-Oct;31(5):1027-1034. doi: 10.21873/invivo.11165.
BACKGROUND/AIM: Type 2 diabetes mellitus (DM) frequently occurs in patients with chronic hepatitis C (CHC) and is associated with atherosclerosis, in which circulating microparticles (MPs) play an important role. We asked whether the presence of DM affects endothelial-derived (EMPs) and platelet-derived microparticles (PMPs) levels; and whether MPs levels associate with biomarkers of inflammation and oxidative stress in patients with CHC.
MATERIALS AND METHODS
Overall, 136 patients were enrolled in the study, 86 CHC patients (41 with DM with moderate glycemic control), 20 outpatients with DM and 30 controls. Circulating MPs were phenotyped by flow cytometry.
RESULTS
When the MPs levels were analyzed individually in CHC patients, there was a positive association of plasma apoptotic MPs with oxidative stress markers. We report a hitherto undescribed relationship between diabetes prevalence and apoptotic MPs-associated inflammation in patients with CHC.
CONCLUSION
The presence of apoptotic MPs in the plasma of CHC patients, with increased levels being found in patients with DM and moderate glycemic control was herein demonstrated. The simultaneous monitoring of plasma apoptotic MPs, oxidative stress markers and inflammatory biomarkers can be helpful for the cardiovascular disease control in diabetic patients with CHC.
背景/目的：2型糖尿病（DM）在慢性丙型肝炎（CHC）患者中频繁发生，且与动脉粥样硬化相关，循环微粒（MPs）在其中起重要作用。我们探讨DM的存在是否会影响内皮细胞衍生微粒（EMPs）和血小板衍生微粒（PMPs）水平；以及MPs水平是否与CHC患者的炎症和氧化应激生物标志物相关。
材料与方法
本研究共纳入136例患者，其中86例CHC患者（41例DM患者且血糖控制适度），20例DM门诊患者和30例对照。通过流式细胞术对循环MPs进行表型分析。
结果
在CHC患者中单独分析MPs水平时，血浆凋亡MPs与氧化应激标志物呈正相关。我们报道了CHC患者中糖尿病患病率与凋亡MPs相关炎症之间一种迄今未描述的关系。
结论
本文证实CHC患者血浆中存在凋亡MPs，且在DM及血糖控制适度的患者中水平升高。同时监测血浆凋亡MPs、氧化应激标志物和炎症生物标志物有助于控制CHC糖尿病患者的心血管疾病。
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