患者来源的膀胱癌异种移植模型
Patient-Derived Bladder Cancer Xenografts.
作者信息
Bernardo Carina, Santos Lúcio Lara
机构信息
Experimental Pathology and Therapeutics Group-Research Center, Portuguese Oncology Institute-Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Institute for Biomedicine (IBiMED), University of Aveiro, Porto, Portugal.
出版信息
Methods Mol Biol. 2018;1655:169-175. doi: 10.1007/978-1-4939-7234-0_14.
Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer research. This chapter describes the methodology to establish and propagate bladder cancer PDX model.
患者来源的异种移植（PDX）肿瘤是通过将人类肿瘤直接移植到免疫缺陷宿主（如裸鼠）中而建立的模型。这些模型保留了原发肿瘤的组织学和遗传学特征，被认为是转化癌症研究的宝贵平台。本章描述了建立和传代膀胱癌PDX模型的方法。
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