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[一例原发性膀胱神经鞘瘤]

[A Case of Primary Schwannoma of the Urinary Bladder].

作者信息

Matsumoto Yoshitaka, Waku Natsui, Kawai Koji, Ikeda Atsushi, Kimura Tomokazu, Ishitsuka Ryutaro, Kojima Takahiro, Suetomi Takahiro, Joraku Akira, Miyazaki Jun, Sakashita Mai, Nishiyama Hiroyuki

机构信息

The Department of Urology and Andrology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.

The Department of Pathology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.

出版信息

Hinyokika Kiyo. 2017 Aug;63(8):323-328. doi: 10.14989/ActaUrolJap_63_8_323.

Abstract

A 68-year-old woman presented with a bladder tumor. She was asymptomatic, and the tumor was incidentally detected with radiological imaging performed during treatment of cervical cancer. Magnetic resonance imaging and computed tomography revealed a solitary submucosal tumor located in the anterior wall of the urinary bladder, with homogeneous contrast enhancement. Cystoscopy showed a submucosal tumor covered by normal mucosa. A paraganglioma was considered in the differential diagnosis, but symptoms suggesting hypercatecholaminemia were not apparent. Moreover, she did not have a family history or symptoms associated with neurofibromatosis-1 (NF-1). She underwent partial cystectomy with a preliminary diagnosis of submucosal bladder tumor. Histopathological diagnosis confirmed a schwannoma arising from the bladder wall. She was followed up without intravesical recurrence or metastases for 6 months. In the literature, only 12 cases of bladder schwannoma have been reported. There was no reported family history or symptoms associated with NF-1 in any of the cases. Although the number of cases is limited, literature review showed a favorable prognosis for bladder schwannoma with local tumor resection in patients without NF-1.

摘要

一名68岁女性因膀胱肿瘤就诊。她没有症状,该肿瘤是在宫颈癌治疗期间进行的放射影像学检查时偶然发现的。磁共振成像和计算机断层扫描显示,膀胱前壁有一个孤立的黏膜下肿瘤,对比增强均匀。膀胱镜检查显示黏膜下肿瘤被正常黏膜覆盖。鉴别诊断考虑为副神经节瘤,但未出现提示高儿茶酚胺血症的症状。此外,她没有神经纤维瘤病1型(NF-1)的家族史或相关症状。她接受了部分膀胱切除术,初步诊断为膀胱黏膜下肿瘤。组织病理学诊断证实为起源于膀胱壁的神经鞘瘤。她接受了6个月的随访,未出现膀胱内复发或转移。在文献中,仅报道了12例膀胱神经鞘瘤病例。所有病例均无NF-1的家族史或相关症状报道。尽管病例数量有限,但文献综述显示,对于无NF-1的患者,局部肿瘤切除术后膀胱神经鞘瘤预后良好。

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