Abdel-Fadeil Mahmoud R, Abedelhaffez Azza S, Makhlouf Hoda A, Al Qirshi Ghada A
Department of Medical physiology, Faculty of Medicine, Assiut University, P.O. Box No. 71526, Assiut, Egypt.
Department of Chest Diseases and TB, Faculty of Medicine, Assiut University, P.O. Box No. 71526, Assiut, Egypt.
Pathophysiology. 2017 Dec;24(4):305-315. doi: 10.1016/j.pathophys.2017.08.003. Epub 2017 Sep 1.
Obstructive sleep apnea (OSA) is a common but often unrecognized condition with potentially serious complications. The aim of this study was to explore the possible mechanisms linking hypertension (HT), a common cardiovascular disease (CVD), with obstructive sleep apnea (OSA) by investigating the levels of morning and evening serum adiponectin, inflammatory markers (TNF-α, IL-6), and lipid profiles in OSA patients with and without HT. Four groups were enrolled in this case-control analytic study: control, OSA, OSA+HT, and HT groups, each of which included 22 subjects. The results revealed low morning and evening serum adiponectin levels in patients with OSA and OSA+HT compared with their control and HT counterparts. Serum adiponectin levels declined progressively with increasing severity of OSA. Also, morning adiponectin levels were significantly decreased at the same time that a loss of the normal diurnal rhythm was observed in the OSA and OSA+HT groups. Both TNF-α and IL-6 levels were significantly increased in the OSA and OSA+HT groups compared with levels in the control and HT groups. Altered lipid profiles was noticed in the same groups. These findings were more pronounced in the OSA+HT than in the OSA group. In conclusion, the biochemical findings of this study demonstrate predominantly low adiponectin levels, increased levels of inflammatory markers, and atherogenic lipid profiles in OSA patients with HT compared with those of the other patients studied. This highlights the possible contributing role of these factors to the pathogenesis of HT as a common cardiovascular complication in OSA patients.
阻塞性睡眠呼吸暂停（OSA）是一种常见但常未被识别的病症，可能引发严重并发症。本研究的目的是通过调查有和没有高血压（HT）的OSA患者的早晚血清脂联素水平、炎症标志物（TNF-α、IL-6）和血脂谱，探索常见心血管疾病（CVD）高血压（HT）与阻塞性睡眠呼吸暂停（OSA）之间可能的关联机制。本病例对照分析研究纳入了四组：对照组、OSA组、OSA+HT组和HT组，每组包括22名受试者。结果显示，与对照组和HT组相比，OSA组和OSA+HT组患者的早晚血清脂联素水平较低。血清脂联素水平随着OSA严重程度的增加而逐渐下降。此外，在OSA组和OSA+HT组中，早晨脂联素水平显著降低，同时观察到正常昼夜节律消失。与对照组和HT组相比，OSA组和OSA+HT组的TNF-α和IL-6水平均显著升高。在同一组中发现血脂谱发生了改变。这些发现在OSA+HT组比OSA组中更为明显。总之，本研究的生化结果表明，与其他研究患者相比，患有HT的OSA患者主要表现为脂联素水平低、炎症标志物水平升高和致动脉粥样硬化的血脂谱。这突出了这些因素在OSA患者中作为常见心血管并发症的HT发病机制中可能的促成作用。
