墨西哥韦拉克鲁斯一家三级护理医院中，术前血清甲胎蛋白水平与肝细胞癌手术治疗后生存率之间的相关性。

Correlation between preoperative serum alpha-fetoprotein levels and survival with respect to the surgical treatment of hepatocellular carcinoma at a tertiary care hospital in Veracruz, Mexico.

作者信息

Martínez-Mier G, Esquivel-Torres S, Nava-Lacorte A, Lajud-Barquín F A, Zilli-Hernández S, Vázquez-Ramírez L M

机构信息

Departamento de Trasplantes de Órganos, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México.

Departamento de Cirugía Oncológica, Unidad Médica de Alta Especialidad (UMAE) 189 Adolfo Ruiz Cortines, Instituto Mexicano del Seguro Social, Veracruz, México.

出版信息

Rev Gastroenterol Mex. 2017 Oct-Dec;82(4):357-360. doi: 10.1016/j.rgmx.2017.03.009.

DOI:10.1016/j.rgmx.2017.03.009

PMID:28893428

Abstract

INTRODUCTION

Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival.

AIM

Our aim was to analyze the correlation between preoperative serum alpha-fetoprotein levels and survival, following the surgical treatment of hepatocellular carcinoma.

METHODS

Nineteen patients were prospectively followed (07/2005-01/2016). An ROC curve was created to determine the sensitivity and specificity of alpha-fetoprotein in relation to survival (Kaplan-Meier).

RESULTS

Of the 19 patients evaluated, 57.9% were men. The mean patient age was 68.1 ± 8.5 years and survival at 1, 3, and 5 years was 89.4, 55.9, and 55.9%. The alpha-fetoprotein cutoff point was 15.1 ng/ml (sensitivity 100%, specificity 99.23%). Preoperative alpha-fetoprotein levels below 15.1, 200, 400, and 463 ng/ml correlated with better 1 and 5-year survival rates than levels above 15.1, 200, 400, and 463 ng/ml (P<.05).

CONCLUSIONS

Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.

摘要

引言

术前血清甲胎蛋白水平对肝细胞癌的生存情况具有预测价值。

目的

我们的目的是分析肝细胞癌手术治疗后术前血清甲胎蛋白水平与生存率之间的相关性。

方法

前瞻性地随访了19例患者（2005年7月至2016年1月）。绘制ROC曲线以确定甲胎蛋白与生存率（Kaplan-Meier法）相关的敏感性和特异性。

结果

在评估的19例患者中，57.9%为男性。患者平均年龄为68.1±8.5岁，1年、3年和5年生存率分别为89.4%、55.9%和55.9%。甲胎蛋白的临界值为15.1 ng/ml（敏感性100%，特异性99.23%）。术前甲胎蛋白水平低于15.1、200、400和463 ng/ml者，其1年和5年生存率高于高于15.1、200、400和463 ng/ml者（P<0.05）。