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遗传性副神经节瘤-嗜铬细胞瘤综合征患者的多模态放射性核素成像。

Multimodality Radionuclide Imaging in a Patient With Hereditary Paraganglioma-Pheochromocytoma Syndrome.

机构信息

From the *Emory University School of Medicine; and †Division of Nuclear Medicine and Molecular Imaging, Department of Radiology & Imaging Sciences, and ‡Division of Endocrinology, Department of Medicine, Emory University, Atlanta, GA.

出版信息

Clin Nucl Med. 2017 Dec;42(12):964-965. doi: 10.1097/RLU.0000000000001841.

Abstract

Hereditary paraganglioma (PGL)-pheochromocytoma (PCC) syndrome is a genetic disorder caused by a mutation of the tumor suppressor gene SDHD that results in a predisposition for head and neck PGLs and PCCs. We present a case of a 33-year-old woman where F-FDG PET/CT showed areas of increased uptake in both the adrenal and cervical regions, consistent with PCCs and PGLs, respectively. Further imaging revealed that PCCs were I-MIBG avid, whereas the PGLs were In-octreotide avid. This demonstrates the varying sensitivities of different imaging modalities in regard to neuroendocrine tumors and the potential for treatment using multiple targeted therapies.

摘要

遗传性副神经节瘤(PGL)-嗜铬细胞瘤(PCC)综合征是一种由肿瘤抑制基因 SDHD 突变引起的遗传疾病,导致头颈部 PGL 和 PCC 的易感性。我们报告了一例 33 岁女性的病例,F-FDG PET/CT 显示肾上腺和颈部区域均有摄取增加,分别符合 PCC 和 PGL 的特征。进一步的影像学检查显示,PCC 对 I-MIBG 摄取增加,而 PGL 对 In-octreotide 摄取增加。这表明不同的影像学检查方法对神经内分泌肿瘤的敏感性不同,并且可以使用多种靶向治疗方法进行治疗。

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