piRNA/PIWI在精子发生中的调控功能。

The regulatory functions of piRNA/PIWI in spermatogenesis.

作者信息

Yuan Zhi-Heng, Zhao Yan-Mei

机构信息

University of Chinese Academy of Sciences, Beijing 100049, China;Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Yi Chuan. 2017 Aug 20;39(8):683-691. doi: 10.16288/j.yczz.17-245.

DOI:10.16288/j.yczz.17-245

PMID:28903896

Abstract

A class of 24-32 nt PIWI-binding small noncoding RNAs (sncRNAs) termed as PIWI-interacting RNAs (piRNAs) have been identified in animal germline. Recent studies suggest that piRNA/PIWI pathway plays a critical role in both silencing of transposons and posttranscriptional regulation of mRNAs in animal germline. A study from Dr. Mofang Liu's lab in Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, reveals the physiological and pathological importance of PIWI metabolism (mouse PIWI as known as MIWI; human PIWI as HIWI) in mammalian spermatogenesis. Here, we summarize our current understanding of the piRNA/PIWI pathway in mammals (focusing on mouse and human), which is emerging as a fundamental component of spermatogenesis that ensures male fertility and genome integrity.

摘要

一类长度为24 - 32个核苷酸的与PIWI蛋白结合的小非编码RNA（sncRNAs），被称为PIWI相互作用RNA（piRNAs），已在动物生殖细胞系中被鉴定出来。最近的研究表明，piRNA/PIWI途径在动物生殖细胞系中转座子沉默和mRNA的转录后调控中都起着关键作用。中国科学院上海生物化学与细胞生物学研究所刘默芳博士实验室的一项研究揭示了PIWI代谢（小鼠PIWI称为MIWI；人类PIWI称为HIWI）在哺乳动物精子发生中的生理和病理重要性。在此，我们总结了目前对哺乳动物（重点是小鼠和人类）piRNA/PIWI途径的理解，该途径正成为精子发生的一个基本组成部分，确保雄性生育能力和基因组完整性。