van Coevorden-Hameete Marleen H, van Beuningen Sam F B, Perrenoud Matthieu, Will Lena M, Hulsenboom Esther, Demonet Jean-Francois, Sabater Lidia, Kros Johan M, Verschuuren Jan J G M, Titulaer Maarten J, de Graaff Esther, Sillevis Smitt Peter A E, Hoogenraad Casper C
Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
Department of Neurology Erasmus University Medical Center Dr. Molewaterplein 403015 GD Rotterdam The Netherlands.
Ann Clin Transl Neurol. 2017 Jul 28;4(9):680-686. doi: 10.1002/acn3.396. eCollection 2017 Sep.
Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.
副肿瘤性神经系统综合征（PNS）通常表现为患者血清或脑脊液中存在抗神经元抗体。抗神经元抗体的检测已被证明是PNS诊断和寻找潜在肿瘤的有用工具。在此，我们描述了三名针对轴突起始段蛋白三方基序46（TRIM46）多个表位具有自身抗体的患者。我们发现，抗TRIM46抗体在常规免疫组织化学筛查中易于检测，并且可以通过蛋白质印迹法和基于细胞的检测方法进行确认。抗TRIM46抗体可出现在患有多种神经系统综合征的患者中，并与小细胞肺癌相关。
