哥伦比亚波哥大两家眼科转诊中心的一组患者中的 Vogt-Koyanagi-Harada 综合征。

Vogt-Koyanagi-Harada Syndrome in a Group of Patients in Two Ophthalmology Referral Centers in Bogotá, Colombia.

机构信息

a Fundación Oftalmológica Nacional (FUNDONAL), Uveitis Service, Bogotá, Columbia.

b Escuela de Medicina y Ciencias de la Salud, Grupo de Investigación en Neurociencias (NeURos), Bogotá, Columbia.

出版信息

Ocul Immunol Inflamm. 2018;26(7):1123-1127. doi: 10.1080/09273948.2017.1341536. Epub 2017 Sep 14.

DOI:10.1080/09273948.2017.1341536

PMID:28910557

Abstract

PURPOSE

To describe the clinical presentation of Vogt-Koyanagi-Harada (VKH) syndrome in a group of patients in Colombia.

METHODS

Retrospective review of 2638 medical records of patients with uveitis in two centers during 17 years.

RESULTS

A total of 25 patients with uveitis were diagnosed with VKH syndrome (0.95%), 23 patients were included in the data analysis (0.87%), 78.3% females, and mean age of diagnosis was 37 years (SD ± 29). Main complaints: blurred vision (87%), headaches (47.8%), tinnitus (26.1%), and hearing impairments (21.7%). Ophthalmic findings: bilateral serous retinal detachment (73.9%) and non-granulomatous uveitis (52.3%). Most of the patients were diagnosed with probable disease (56.5%). Mean duration of follow-up was 14 months; disease relapse was encountered in 26% of patients despite treatment.

CONCLUSION

Patients in Colombia with VKH had clinical features similar to those reported in other Hispanic populations, except for the non-granulomatous uveitis. This disease may be considered as having variation of clinical manifestations across population groups.

摘要

目的

描述哥伦比亚一组患者 Vogt-Koyanagi-Harada（VKH）综合征的临床表现。

方法

对两个中心 17 年间 2638 例葡萄膜炎患者的病历进行回顾性分析。

结果

共诊断出 25 例 VKH 综合征患者（0.95%），其中 23 例纳入数据分析（0.87%），女性占 78.3%，诊断时的平均年龄为 37 岁（标准差±29）。主要症状：视力模糊（87%）、头痛（47.8%）、耳鸣（26.1%）和听力障碍（21.7%）。眼部表现：双侧浆液性视网膜脱离（73.9%）和非肉芽肿性葡萄膜炎（52.3%）。大多数患者被诊断为可能的疾病（56.5%）。平均随访时间为 14 个月；尽管进行了治疗，但仍有 26%的患者出现疾病复发。