苯丙胺类兴奋剂使用障碍中的内源性大麻素机制：简短综述。
Endocannabinoid mechanism in amphetamine-type stimulant use disorders: A short review.
作者信息
Su Hang, Zhao Min
机构信息
Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Collaborative Innovation Center for Brain Science, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
出版信息
J Clin Neurosci. 2017 Dec;46:9-12. doi: 10.1016/j.jocn.2017.08.042. Epub 2017 Sep 12.
Recent evidence shows that the endocannabinoid system is involved in amphetamine-type stimulants (ATS) use disorders. To elucidate the role of the endocannabinoid system in ATS addiction, we reviewed results of studies using cannabinoid receptor agonists, antagonists as well as knockout model. The endocannabinoid system seems to play a role in reinstatement and relapse of ATS addiction and ATS-induced psychiatric symptoms. The molecular mechanisms of this system remains unclear, the association with dopamine system in nucleus accumbens is most likely involved. However, the function of the endocannabinoid system in anxiety and anti-anxiety effects induced by ATS is more complicated. These findings suggest that the endocannabinoid system may play an important role in the mechanism of ATS addiction and provide new idea for treating ATS addiction.
近期证据表明，内源性大麻素系统与苯丙胺类兴奋剂（ATS）使用障碍有关。为阐明内源性大麻素系统在ATS成瘾中的作用，我们回顾了使用大麻素受体激动剂、拮抗剂以及基因敲除模型的研究结果。内源性大麻素系统似乎在ATS成瘾的复吸及复发以及ATS诱导的精神症状中发挥作用。该系统的分子机制尚不清楚，很可能与伏隔核中的多巴胺系统有关。然而，内源性大麻素系统在ATS诱导的焦虑和抗焦虑作用中的功能更为复杂。这些发现表明，内源性大麻素系统可能在ATS成瘾机制中发挥重要作用，并为治疗ATS成瘾提供了新思路。
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