肝外胆管癌中包膜外淋巴结侵犯和肌成纤维细胞活性的预后影响
Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer.
作者信息
Yoshizawa Tadashi, Ishido Keinosuke, Saito Kensuke, Haga Toshihiro, Seino Hiroko, Wu Yunyan, Morohashi Satoko, Hakamada Kenichi, Kijima Hiroshi
机构信息
Department of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Department of Gastroenterological Surgery, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
出版信息
Clin Med Insights Pathol. 2017 Sep 6;10:1179555717729652. doi: 10.1177/1179555717729652. eCollection 2017.
Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.
肝外胆管癌是一种潜在的恶性胃肠道病变。癌细胞通过淋巴系统扩散至区域淋巴结，促进肿瘤进展。然而，关于这种癌症中包膜外淋巴结侵犯和肌成纤维细胞活性对预后的影响尚无报道。因此，我们将淋巴结的组织病理学模式分为两种：有无包膜外淋巴结侵犯。基于此，我们调查了32例有淋巴结转移的肝外胆管癌病例，将21例分类为阳性，11例分类为阴性。包膜外淋巴结侵犯病例的无病生存期和总生存期较差。包膜外淋巴结侵犯病例转移灶的肌成纤维细胞密度显著更高。这是第一项表明包膜外淋巴结侵犯病例预后较差且肌成纤维细胞分布促进恶性肿瘤发展的研究。
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