影响单剂量甲氨蝶呤治疗异位妊娠成功率的因素的回顾性分析。

Retrospective analysis of factors that affect the success of single-dose methotrexate treatment in ectopic pregnancy.

作者信息

Var Altan, Özyurt Ramazan, Şık Bulat Aytek, Kumbasar Serkan, Sever Erman, Deveci Mustafa, Çöt Özgür, Salman Süleyman, Güzel Yılmaz

机构信息

İstanbul Research and Education Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.

İstanbul Aydın University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.

出版信息

Turk J Obstet Gynecol. 2015 Dec;12(4):215-219. doi: 10.4274/tjod.10576. Epub 2015 Dec 15.

DOI:10.4274/tjod.10576

PMID:28913072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5588474/

Abstract

OBJECTIVE

Detection of factors that affect the success of single-dose methotrexate treatment in ectopic pregnancy.

MATERIALS AND METHODS

We investigated 99 patients who had been treated with single-dose methotrexate for ectopic pregnancy in our clinic between January 2009 and June 2014. Demographic, clinical, and laboratory results of possible factors that affect treatment success were retrospectively analyzed. Successfully and unsuccessfully treated patients were compared based on their pre-treatment results.

RESULTS

The success rate of single-dose methotrexate treatment was found to be 70.7%. No significant difference was found between succesfully and unsuccessfully treated patients before treatment in terms of factors such as gestational weeks, mass size, presence of yolk sac, and presence of free fluid (p=0.224, p=0.201, p=0.200, p=0.200). Serum β-hCG values in patients whose treatment was unsuccessful was found to be higher compared with the successfully treated group (mean β-hCG value of unsuccessful group: 4412±3501 mIU/mL; mean β-hCG value of successful group: 1079±942 mIU/mL; p<0.001).

CONCLUSION

Single-dose methotrexate treatment is an effective and reliable method in the treatment of ectopic pregnancy. Elevation of serum β-hCG value stands as the main prognostic factor that affects the success of single-dose methotrexate treatment.

摘要

目的

检测影响单剂量甲氨蝶呤治疗异位妊娠成功率的因素。

材料与方法

我们调查了2009年1月至2014年6月期间在我们诊所接受单剂量甲氨蝶呤治疗异位妊娠的99例患者。回顾性分析了可能影响治疗成功的人口统计学、临床和实验室结果。根据治疗前结果对治疗成功和失败的患者进行比较。

结果

发现单剂量甲氨蝶呤治疗的成功率为70.7%。在孕周、包块大小、卵黄囊的存在以及游离液体的存在等因素方面，治疗成功和失败的患者在治疗前没有显著差异（p = 0.224，p = 0.201，p = 0.200，p = 0.200）。与治疗成功的组相比，治疗失败的患者血清β - hCG值更高（失败组的平均β - hCG值：4412±3501 mIU/mL；成功组的平均β - hCG值：1079±942 mIU/mL；p < 0.001）。