Tseng Yun-An, Lawrence W Dwayne, Slater Shahrzad E
Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.
Int J Gynecol Pathol. 2018 Nov;37(6):554-558. doi: 10.1097/PGP.0000000000000456.
Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. All cases have microscopic features of lobular proliferation of acini and inspissated mucin. One case especially has extensive mucin extravasation mimicking an aggressive angiomyxoma. In this case series, we call attention to NH as another entity to consider in the differential diagnosis of an enlarged Bartholin gland. We also discuss ways to distinguish it from other benign and malignant solid lesions of the vulvar vestibule.
巴氏腺结节状增生（NH）是女性生殖道极为罕见的良性实性病变，临床上可酷似巴氏腺囊肿。1998年，凯尼格和塔瓦索利确立了NH的组织学标准。在本病例系列中，我们描述了罗德岛妇女和婴儿医院的4例NH病例。所有病例均具有腺泡小叶增生和黏液浓缩的微观特征。其中1例尤其有广泛的黏液外渗，酷似侵袭性血管黏液瘤。在本病例系列中，我们提醒注意NH是巴氏腺肿大鉴别诊断中需考虑的另一种病变。我们还讨论了将其与外阴前庭其他良恶性实性病变相鉴别的方法。
