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紧急神经生命支持:脑膜炎和脑炎。

Emergency Neurologic Life Support: Meningitis and Encephalitis.

机构信息

Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

出版信息

Neurocrit Care. 2017 Sep;27(Suppl 1):124-133. doi: 10.1007/s12028-017-0455-y.

Abstract

Bacterial meningitis and viral encephalitis, particularly herpes simplex encephalitis, are severe neurological infections that, if not treated promptly and effectively, lead to poor neurological outcome or death. Because of the value of early recognition and treatment, meningitis and encephalitis was chosen as an Emergency Neurological Life Support protocol. This protocol provides a practical approach to recognition and urgent treatment of bacterial meningitis and encephalitis. Appropriate imaging, spinal fluid analysis, and early empiric treatment are discussed. Though uncommon in its full form, the typical clinical triad of headache, fever, and neck stiffness should alert the clinical practitioner to the possibility of a central nervous system infection. Early attention to the airway and maintaining normotension are crucial steps in the treatment of these patients, as is rapid treatment with anti-infectives and, in some cases, corticosteroids.

摘要

细菌性脑膜炎和病毒性脑炎,特别是单纯疱疹性脑炎,是严重的神经系统感染,如果不能及时、有效地治疗,会导致不良的神经预后或死亡。由于早期识别和治疗的重要性,脑膜炎和脑炎被选为急诊神经生命支持方案。本方案为细菌性脑膜炎和脑炎的识别和紧急治疗提供了实用方法。讨论了适当的影像学检查、脑脊液分析和早期经验性治疗。虽然不常见,但头痛、发热和颈项强直的典型三联征应引起临床医生对中枢神经系统感染的可能性的警惕。早期关注气道和维持正常血压是治疗这些患者的关键步骤,快速使用抗感染药物治疗,在某些情况下使用皮质类固醇也是如此。

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