可见光介导的N-甲基腺嘌呤氧化去甲基化反应
Visible-light-mediated oxidative demethylation of N-methyl adenines.
作者信息
Xie Li-Jun, Wang Rui-Li, Wang Dong, Liu Li, Cheng Liang
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2017 Sep 26;53(77):10734-10737. doi: 10.1039/c7cc05544g.
We report a simple protocol that affords oxidative demethylation of N-methyl groups in N-methyl adenines (mA). The biologically compatible photocatalyst riboflavin prompts a highly selective C-H abstraction from N-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of mA and related N-methyl adenine analogues.
我们报道了一种简单的方法，该方法可实现N-甲基腺嘌呤（mA）中N-甲基的氧化去甲基化。具有生物相容性的光催化剂核黄素在可见蓝光LED照射下，促使腺嘌呤中N-甲基的C-H发生高度选择性的抽象，从而实现了mA及相关N-甲基腺嘌呤类似物的新型高选择性仿生去甲基化。
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