Eustace Ronan, Rubin Jacob, Thompson Kimberly A, Snowdon Kyle, Sikarskie James G, Monahan Colleen, Smedley Rebecca C
J Zoo Wildl Med. 2017 Sep;48(3):906-909. doi: 10.1638/2016-0242.1.
A renal tubular cystadenoma was diagnosed in a 14-yr-old male African lion (Panthera leo). During a routine health evaluation, a left renal mass was identified via physical examination, radiographs, and abdominal ultrasonography. The mass was 30 × 15 cm in size and had a thin capsule with central hypoechoic fluid, suggestive of a perirenal cyst. An exploratory celiotomy with partial nephrectomy was performed without complications. Histologically, the tumor was characterized by a thick fibrous capsule surrounding multiple, variable-sized cysts that markedly compressed the adjacent fibrotic and atrophied renal cortex. Immunohistochemical labeling for Aquaporin-1 and Tamm-Horsfall protein was consistent with a renal tubular cystadenoma of proximal tubule origin. Renal cystadenomas are an uncommon benign epithelial neoplasm. There are only two documented case reports in domestic cats. This report represents the first documentation, to the authors' knowledge, of a renal cystadenoma in a lion.
一只14岁的雄性非洲狮(Panthera leo)被诊断出患有肾小管囊腺瘤。在一次常规健康评估中,通过体格检查、X光片和腹部超声检查发现左肾有一个肿块。该肿块大小为30×15厘米,有一层薄包膜,中央为低回声液性区,提示为肾周囊肿。进行了剖腹探查并部分肾切除术,未出现并发症。组织学上,肿瘤的特征是有一层厚厚的纤维包膜,围绕着多个大小不一的囊肿,这些囊肿明显压迫了相邻的纤维化和萎缩的肾皮质。水通道蛋白-1和Tamm-Horsfall蛋白的免疫组织化学标记与近端小管起源的肾小管囊腺瘤一致。肾囊腺瘤是一种罕见的良性上皮性肿瘤。家猫中仅有两份文献记载的病例报告。据作者所知,本报告是首例关于狮子患肾囊腺瘤的记录。