Department of Basic Health Sciences, Laboratory of Parasitology, Universidade Estadual de Maringá, Avenida Colombo, 5790, Jd. Universitário, bloco I90, sala 11, 87020-900 Maringá, Paraná, Brazil.
Microb Pathog. 2017 Nov;112:1-4. doi: 10.1016/j.micpath.2017.09.026. Epub 2017 Sep 18.
Studies show that highly diluted medications demonstrate benefits in treating infections, constituting an alternative for their treatment. The present study evaluated the effects of Lycopodium clavatum, dynamization 13c, in Wistar rats infected with T. cruzi. In this study 42 male rats were intraperitoneally inoculated with T. cruzi - Y strain and allocated into groups: IC (infected control group) and Ly (treated with L. clavatum 13c). The cytokines dosage (IFN-γ, IL-12, IL-10, IL-4), quantification and morphometry of myenteric neurons were evaluated. The treatment with L. clavatum modifies the immune response, with increase of IFN-γ on day 10 a.i. and IL-12 on day 24 a.i., decrease of IL-10 concentration on day 10 a.i. and subsequent increase of this cytokine and IL-4 on day 24 a.i., affording a bigger number of myenteric neurons compared to IC group. Thus, L. clavatum 13c promoted on rats infected with T. cruzi a beneficial immunomodulatory action reducing the pathogenic progression of digestive Chagas disease.
研究表明，高度稀释的药物在治疗感染方面具有益处，可作为其治疗的替代方法。本研究评估了 Lycopodium clavatum （喇叭茶属植物）经 13C 动力处理后对感染 T. cruzi 的 Wistar 大鼠的影响。在这项研究中，42 只雄性大鼠通过腹腔内接种 T. cruzi - Y 株，并分为两组：IC（感染对照组）和 Ly（用 L. clavatum 13c 治疗组）。评估了细胞因子（IFN-γ、IL-12、IL-10、IL-4）的剂量、定量和肌间神经元的形态计量学。L. clavatum 的治疗改变了免疫反应，在感染后第 10 天增加 IFN-γ，第 24 天增加 IL-12，第 10 天减少 IL-10 浓度，随后增加该细胞因子和 IL-4，与 IC 组相比，大鼠的肌间神经元数量增加。因此，L. clavatum 13c 对感染 T. cruzi 的大鼠具有有益的免疫调节作用，可降低消化性恰加斯病的发病进程。
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